Dr. Vlad Toma

Dr. Vlad Toma

Scientific researcher III
INSTITUTE OF BIOLOGICAL RESEARCH – ICB Cluj-Napoca

Dr. Toma’s research specializes in hypoxia and ischemia within the nervous and cardiovascular systems. His work initially focused on hemoglobin-based oxygen transporters and their role in ischemic processes, particularly in the brain and myocardium.

Email:

vlad.toma@icbcluj.ro

  • REASEARCH
  • PROJECTS
  • PUBLICATIONS
My research focuses on the cell biology of the neurovascular system in health and disease, with a particular emphasis on the role of globin biochemistry in the progression of neurodegenerative disorders, vascular dysfunctions, and metabolic alterations.
    • AOSR-TEAMS-III 2024-2025: Mitochondrial Genomic Profile of CD19+ B Lymphocytes in Type 2 Diabetes Patients with Angiopathic Risk and Sorbitol Cellular Metabolism – Computational Innovation, Multisource Validation, and Novel Targets for Prediagnosis – Project Director.
     
    • Maya and Nicolae Simionescu Biomedical Research Grant (2022-2023): In Search for a Strategy Based on the Fenton Haber-Weiss Reaction to Re-educate Melanoma-Associated Fibroblasts Using In Vitro 3D Models – Project Director.
     
    • Postdoctoral Research Project PFE-550-UBB (2022-2023): Artificial Peroxisome and Cell Implants – Project Director.
     
    • GTC Young Researchers Grant, Babeș-Bolyai University (2023-2025): Statins as Peroxisome Proliferators – Project Director.
     
    • Toma, V., Farcaş, A., Roman, I., Sevastre, B., Hathazi, D., Scurtu, F., Damian, G., Silaghi-Dumitrescu, R. Comparative in vivo effects of hemoglobin-based oxygen carriers (HBOC) with varying prooxidant and physiological reactivity. PloS ONE, 11(4), 2016, 1-16.
     
    • Toma, VA., Farcas, A, Parvu, M., Silaghi-Dumitrescu, R., Roman, I. CA3 hippocampal field: Cellular changes and its relation with blood nitro-oxidative stress reveal a balancing function of CA3 area in rats exposed to repeated restraint stress. Brain Res Bull., 130, 2017, 10-17.
     
    • Toma, V. A., Farcas, A.D., Roman, I., Sevastre, B., Hathazi, D., Scurtu, F., Damian, G., Silaghi-Dumitrescu, R., In vivo evaluation of hemerythrin-based oxygen carriers: similarities with hemoglobin-based counterparts. Int. J. Biol.Macromol., S0141-8130(17), 2017, 31756-7.
     
    • Farcas, A. D., Toma, V. A., Roman, I., Sevastre, B., Scurtu, F., & Silaghi-Dumitrescu, R. (2020). Glutaraldehyde-Polymerized Hemoglobin: In Search of Improved Performance as Oxygen Carrier in Hemorrhage Models. Bioinorganic Chemistry and Applications, 2020.
     
    • Dionisie, V., Ciobanu, A. M., Toma, V. A., Manea, M. C., Baldea, I., Olteanu, D., ... & Filip, G. A. (2021). Escitalopram targets oxidative stress, caspase-3, BDNF and MeCP2 in the hippocampus and frontal cortex of a rat model of depression induced by chronic unpredictable mild stress. International Journal of Molecular Sciences, 22(14), 7483.
     
    • Toma, V. A., Colnita, A., Brezestean, I., Dume, B., Roman, I., & Turcu, I. (2021). The complementary role of the RAMAN microspectroscopy to the oxidative stress assays in neonatal synaptosome characterization. Studia Universitatis Babes-Bolyai, Chemia, 66(3).
     
    • Toma, V. A., Dume, B., Trâncă, R., Sevastre, B., Barbu, L., Filip, G. A., ... & Sevastre-Berghian, A. C. (2022). The Effect of Repeated Restraint Stress on Neuroglobin-Oligodendrocytes Functions in the CA3 Hippocampal Area and Their Involvements in the Signaling Pathways of the Stress-Induced Anxiety. Applied Sciences, 12(17), 8680.
     
    • Lupu, M., Tudor, D. V., Toma, V. A., Florea, A., Lupsor, A., Moldovan, R., ... & Filip, A. G. (2022). Iron chelation effects on lipid peroxidation, inflammation and ventricular performance in a rat model of isoproterenol induced acute myocardial stress. Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society, 73(3).
     
    • Sevastre-Berghian, A. C., Ielciu, I., Bab, T., Olah, N. K., Neculicioiu, V. S., Toma, V. A., ... & Băldea, I. (2023). Betula pendula Leaf Extract Targets the Interplay between Brain Oxidative Stress, Inflammation, and NFkB Pathways in Amyloid Aβ1-42-Treated Rats. Antioxidants, 12(12), 2110.
     
    • Florea, C. M., Rosu, R., Moldovan, R., Vlase, L., Toma, V., Decea, N., ... & Filip, G. A. (2024). The impact of chronic Trimethylamine N-oxide administration on liver oxidative stress, inflammation, and fibrosis. Food and Chemical Toxicology, 114429.
     
    • Roman, I., Moldoveanu, C. A., Drăgan, Ș., Baumli, J., Cimpoiu, C., & Toma, V. A. (2024). Neurotrophic effects of iridoid glycosides from Lamium album L. as natural GLP1-R modulators in repeated restraint stress. Studia Universitatis Babes-Bolyai, Chemia, 69(3)

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